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Matthew S. Hickey, Ph.D.

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Research Interests

• My laboratory, in collaboration with colleagues, studies the following areas related to human metabolism:

1. The role of changes in dietary fat type (i.e., increased omega-3 fatty acids or decreased saturated fat) on insulin sensitivity and markers of both subclinical inflammation and endothelial dysfunction.
2. Post-receptor signaling events in human skeletal muscle (i.e., insulin signaling, translation initiation) in response to changes in diet and physical activity.
3. Ethnic differences in risk for the metabolic syndrome, diabetes, and cardiovascular disease.
4. Diet, exercise, and nutrient partitioning.

Education

• 1988, B.S., Exercise Science, Western Carolina University, Cullowhee, NC
• 1990, M.S., Exercise Physiology, Virginia Polytechnic Institute and State University, Blacksburg, VA
• 1993, Ph.D., Bioenergetics, Ball State University, Muncie, IN

Professional Experience

• 1993-1995, NIH Post-Doctoral Fellow, Department of Biochemistry, East Carolina University.
• 1995, Visiting Assistant Professor, Human Performance Laboratory, East Carolina University.
• 1996, Assistant Professor, Human Performance Laboratory, East Carolina University.
• 1997-2000, Assistant Professor, Department of Health and Exercise Science, Colorado State University.
• 2001-Present, Associate Professor, Department of Health and Exercise Science, Colorado State University.
• 1997-Present, Joint Academic Appointment, Departments of Food Science and Human Nutrition and Physiology, Colorado State University.
• 1997-Present, Director, Exercise Science and Nutrition Interdisciplinary Graduate Program. Departments of Health and Exercise Science and Food Science and Human Nutrition, Colorado State University.
• 1997-Present, Director, Human Performance Clinical/Research Laboratory, Department of Health and Exercise Science, Colorado State University

Honors and Awards

• 1988, Summa Cum Laude Graduate, Western Carolina University.
• 1994, National Research Service Award, National Institute of Health
• 1995, Young Investigator Travel Award. Federation of American Societies for Experimental Biology Summer Research Conference. Genetic and Behavioral Influences on Nutrient Metabolism and Obesity. Copper Mountain, CO.
• 1998, Elected Fellow of the American College of Sports Medicine (FACSM).
• 1998, Named Fellow, North American Association for the Study of Obesity (NAASO).
• 1998, Outstanding Young Alumni, Western Carolina University.
• 2000, President, Rocky Mountain Chapter, American College of Sports Medicine.
• 2001, College of Applied Human Sciences Tenure-Track Faculty Teaching Excellence Award, Colorado State University.
• 2002, Colorado State University Alumni Association Best Teacher Award

Current Classes Taught

• EX 403 Physiology of Exercise
• EX/FN 560 Exercise and Nutrition (team taught with Dr. Melby from Nutrition)
• EX 610 Bioenergetics
• EX 696EV Group Study-Exercise and Nutrition

Selected Recent Publications

• M.S. Hickey, C.J. Tanner, S.D. O’Neill, L.J. Morgan, G.L. Dohm, and J.A. Houmard. Activation of phosphatidylinositol 3-kinase in human skeletal muscle in-vivo. J. Appl. Physiol. 83(3): 718-722, 1997.
• R. N. Cortright, J. L. Azevedo, Jr., M. S. Hickey, E. B. Tapscott, and G. L. Dohm. Vanadate stimulation of 2-deoxyglucose transport is not mediated by PI3-kinase in human skeletal muscle. Biochem. Biophys. Acta. 1358: 300-306, 1997
• M. S. Hickey, W.J. Pories, K.G. MacDonald, K.A. Cory, G.L. Dohm, M.S. Swanson, R.G. Israel, H.A. Barakat, R.V. Considine, J.F. Caro, and J.A. Houmard. A new paradigm for Type 2 diabetes mellitus: could it be a disease of the foregut? Annals of Surgery 227(5): 637-644, 1998.
• J.A. Houmard, D.S. O’Neill, D. Zheng, M.S. Hickey, and G.L. Dohm. Impact of hyperinsulinemia on myosin heavy chain gene regulation. J. Appl. Physiol. 86(6): 1828-1832, 1999.
• Houmard. J.A., C.D.Shaw, M.S. Hickey, and C.J. Tanner. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle. Am. J. Physiol. 277: E1055-E1060, 1999.
• L. Cordain, L. Toohey, M. Smith & M. Hickey. Dietary regulation of immune function in rheumatoid arthritis. Br. J. Nutr. 83:207-217, 2000.
• N. R Guesbeck, M. S. Hickey, K.G. MacDonald, W.J. Pories, I. Harper, E. Ravussin, G. L. Dohm, and J. A. Houmard. Substrate utilization during exercise in formerly morbidly obese women. J. Appl. Physiol. 90: 1007-1012, 2001.
• M.S. Hickey and D.J. Calsbeek. Plasma Leptin and Exercise: Recent Findings. Sports Medicine. Invited Review. 31(8): 583-589, 2001.
• DJ Calsbeek, TL Thompson, JA Dahl, NR Stob, JT Brozinick Jr., JO Hill, and MS Hickey. Metabolic and anthropometric factors related to skeletal muscle UCP-3 gene expression in healthy human adults. Am. J. Physiol. Endocrinol. & Metab. 283(4): 631-637, 2002.
• RC Ho, KP Davy, MS Hickey, SR Summers, and CL Melby. Behavioral, metabolic, and molecular correlates of lower insulin sensitivity in Mexican Americans. Am. J. Physiol. Endocrinol. & Metab. 283(4): 799-808, 2002.
• M.S. Hickey and R.G. Israel. Exercise and Adipose Tissue Production of Cytokines. In: Endurance Exercise and Adipose Tissue. Ed. B.J. Nicklas. CRC Press. pp. 79-100, 2002. Invited Book Chapter.
• TL Nelson & MS Hickey. Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. Cytokine 26: 195-201. 2004.
• G. Hoyt, M. Hickey, and L. Cordain. Dissociation of the glycemic and insulinemic indices to skim and whole milk. Br. J. Nutr. 93: 205-207, 2005.
• R. Ho, K. Davy, M. Hickey, and C. Melby. Circulating Tumor Necrosis Factor Alpha is Higher in Non-Obese, Non-Diabetic Mexican Americans Compared to Non-Hispanic White Adults Cytokine. In press.