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Frank A. Dinenno, Ph.D.

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Research Interests

• The control of vascular tone during various stressors (e.g., exercise, hypoxia) in humans. Specifically, understanding how the sympathetic nervous system and “local” factors interact to control vascular tone and muscle blood flow, how these interactions are altered with aging, and how regular physical activity impacts on these control mechanisms.
• The effects of aging and lifestyle factors (e.g., regular physical activity) on overall cardiovascular structure and function, and how these effects relate to human health and disease.
• For more information on Dr. Dinenno’s research, please visit the Human Cardiovascular Physiology Laboratory website.

Education

• 1996, B.S., Exercise Science, University of Arizona, Tucson, AZ.
• 1998, M.S., Cardiovascular Physiology, Department of Kinesiology, University of Colorado at Boulder, Boulder, CO.
• 2000, Ph.D., Cardiovascular Physiology, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO.

Professional Experience

• 1995-1996, Student Research Intern, University of Arizona/NASA Space Grant Research Program, University of Arizona, Tucson, AZ.
• 1996-1997 Intern, University/Community Health and Wellness Evaluation Program, University of Colorado, Boulder, CO.
• 1997-1998, Teaching Assistant, Department of Kinesiology, University of Colorado, Boulder, CO.
• 1998-2000, Research Assistant, Human Cardiovascular Research Laboratory, University of Colorado, Boulder, CO.
• 2000-2003, Postdoctoral Research Fellow, Anesthesia Research, Mayo Clinic and Foundation, Rochester, MN.
• 2004-present, Assistant Professor, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO.

Honors and Awards

• 1999, Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society.
• 1999, Glenn/AFAR Scholarship for Research in the Biology of Aging: “Femoral Artery Intima-Media Thickness: Effects of Aging and Habitual Physical Activity”, American Federation for Aging Research.
• 2001, Travel Award for the XXXIV International Congress of Physiological Sciences (Christchurch, New Zealand), American Physiological Society.
• 2001, Michael J. Brody Young Investigator Award (finalist), American Physiological Society.
• 2002, Recognition Award for Meritorious Research by a Young Investigator, Neural Control and Autonomic Regulation Section of the American Physiological Society.
• 2002, Clinical Science Young Investigator Award, Cardiovascular Section of the American Physiological Society.
• 2000-2003, Individual National Research Service Award (F32) - National Institute on Aging, NIH.
• 2002-2006, Clinical Loan Repayment Program Award, National Institutes of Health
• 2004, New Investigator Award, Environmental and Exercise Physiology Section of the American Physiological Society.

Current Funding

• 2003 - 2008, Research Career Award (K01) - National Institute on Aging, NIH: “Aging and Sympathetic Vasoconstriction: rest vs exercise.”

Professional Societies

• American Physiological Society
• American College of Sports Medicine
• American Heart Association

Selected Recent Publications

• Dinenno, F.A., P.P. Jones, D.R. Seals, and H. Tanaka. Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation. 100: 164-170, 1999.
• Dinenno, F.A., H. Tanaka, K.D. Monahan, C.M. Clevenger, I. Eskurza, C.A. DeSouza, and D.R. Seals. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J. Physiol. 534: 287-295, 2001.
• Dinenno, F.A., H. Tanaka, B.L. Stauffer, and D.R. Seals. Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J. Physiol. 536: 977-983, 2001.
• Dinenno, F.A., J.H. Eisenach, N.M. Dietz, and M.J. Joyner. Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men. J. Physiol. 54: 1103-1110, 2002.
• Dinenno, F.A., N.M. Dietz, and M.J. Joyner. Aging and forearm post-junctional alpha-adrenergic vasoconstriction in healthy men. Circulation. 106: 1349-1354, 2002.
• Rosenmeier, J.B., F.A. Dinenno, S.J. Fritzlar, and M.J. Joyner. alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle. J. Physiol. 547: 971-976, 2003.
• Dinenno, F.A., M.J. Joyner, and J.R. Halliwill. Failure of systemic hypoxia to blunt alpha-adrenergic vasoconstriction in the human forearm. J. Physiol. 549: 985-94, 2003.
• Halliwill, J.R., F.A. Dinenno, and N.M. Dietz. Alpha-adrenergic vascular responsiveness during postexercise hypotension in humans. J. Physiol. 550: 279-286, 2003.
• Dinenno, F.A., and M.J. Joyner. Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory? J. Physiol. 553: 281-292, 2003.
• Dinenno, F.A. Hypoxic regulation of blood flow in humans: alpha-adrenergic receptors and functional sympatholysis in skeletal muscle. Adv. Exp. Med. Biol. 543: 237-248, 2003.
• Dinenno, F.A. Ageing, exercise training, and resistance vessels: more than just no NO? J. Physiol. 556: 673, 2004.
• Schrage, W.G., M.J. Joyner, and F.A. Dinenno. Local inhibition of nitric oxide and prostaglandins independently reduce forearm exercise hyperaemia in humans. J. Physiol. 557: 599-611, 2004.
• Charkoudian, N., E.A. Martin, F.A. Dinenno, J.H. Eisenach, N.M. Dietz, and M.J. Joyner. Influences of increased central venous pressure on baroreflex control of sympathetic activity in humans. Am. J. Physiol. Heart Circ. Physiol. In press.
• Dinenno, F.A., and M.J. Joyner. Combined nitric oxide and prostaglandin inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscle. Am. J. Physiol. Heart Circ. Physiol. 287: H2576-H2584, 2004.
• Seals, D.R., and F.A. Dinenno. Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am. J. Physiol. Heart Circ. Physiol. 287: H1895-H1905, 2004.

For the complete list of publications:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed