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Christopher Bell, Ph.D.

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Research Interests

• The regulation of energy expenditure by the sympathetic nervous system, and how this is influenced by aging, habitual exercise, molecular and genetic properties of beta-adrenergic receptors, and oxidative stress.

Education

• 1999 - 2004 Post-Doctoral Research Fellow, Department of Integrative Physiology, University of Colorado, USA
• 1994 -1999 Ph.D. Centre for Activity and Ageing, School of Kinesiology, University of Western Ontario, Canada
• 1992- 1994 M.Sc. Department of Exercise and Sport Science, Manchester Metropolitan University, UK
• 1988- 1991 B.Sc. (Hons) Crewe+Alsager College of Higher Education, UK

Professional Organizations

• The American Physiological Society
• American College of Sports Medicine
• American Heart Association
• North American Association for the Study of Obesity

Awards and Fellowships

• 2006 - 2009 United States Department of Agriculture Colorado Agricultural Experiment Station $120,925
• 2006 - 2007 Diabetes & Endocrinology Research Center Pilot and Feasibility Award $50,000
• 2004 - 2009 National Institute on Aging: Mentored Research Scientist Development Award (K01) $568,570
• 2002 - 2003 American Heart Association: Post-Doctoral Fellowship $41,966
• 2002 - 2003 Clinical Nutrition Research Unit: Pilot and Feasibility Project $38,000
• 1999 - 2001 American Heart Association: Post-Doctoral Fellowship $70,000

Selected Recent Publications

• Bell, C., N.R. Stob, and D.R. Seals. Thermogenic Responsiveness to Non-Specific Beta-Adrenergic Stimulation is Not Related to Genetic Variation in Codon 16 of the Beta2-Adrenergic Receptor. American Journal of Physiology: Endocrinology and Metabolism 290(4): E703-7, 2006.
• Bell, C., N.R. Stob, and D.R. Seals. Thermogenic Responsiveness to Beta-Adrenergic Stimulation is Augmented in Exercising vs. Sedentary Adults: Role of Oxidative Stress. Journal of Physiology 570.3: 629?635, 2006.
• Bell,C., Carson,J.M., Motte, N.W., and Seals, D.R. Ascorbic Acid Does Not Affect The Age-Associated Reduction In Maximal Cardiac Output And Oxygen Consumption In Healthy Adults. Journal of Applied Physiology, 98(3):845-849, 2005.
• Bell,C., Day, D.S.,Jones, P.P., Christou, D.D., Petitt, D.S., Osterberg, K., Melby, C.L.,and Seals, D.R. High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults. Journal of ClinicalEndocrinology and Metabolism, 89(7):3573-3578, 2004.
• Seals,D.R., and Bell, C. Chronic sympathetic activation: Consequence and cause of age-associated obesity. Diabetes, 53(2):276-284, 2004.
• Bell,C., Petitt,D.S., Jones, P.P., and Seals, D.R. Influence of adiposity on tonic sympathetic support of resting metabolic rate in healthy adults. International Journal of Obesity and Related Metabolic Disorders, 27: 1315-1318, 2003.
• Bell,C., Jones,P.P., and Seals, D.R. Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic nerve activity with primary aging in adult humans. Journal of Clinical Endocrinology and Metabolism, 88:4950-4954, 2003.
• Bell,C., Monahan,K.D., Donato, A.J., Hunt, B.E., Seals, D.R., and Beck, K.C. Use of acetylene breathing to determine cardiac output in young and older adults. Medicine and Science in Sports and Exercise, 35: 58-64, 2003.
• Scheuermann, B.W., Bell, C.,Paterson, D.H., Barstow, T.J. and Kowlachuk, J.M. Oxygen uptake kinetics for moderate exercise are speeded in older humans by prior heavy exercise. Journal of Applied Physiology 92: 609-616, 2002.
• Seals, D.R., Monahan, K.D., Bell, C., Tanaka, H. and Jones, P.P. The aging cardiovascular system: Changes in autonomic function at rest and in response to exercise. International Journal of Sport Nutrition and Exercise Metabolism 11, S189-S195, 2001.
• Bell,C., Seals,D.R., Monroe, M.B., Day, D.S., Shapiro, L.F., Johnson, D.G., and Jones, P.P. Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. Journal of Clinical Endocrinology and Metabolism 86: 4440-4444, 2001.
• Bell,C., Paterson,D.H., Kowalchuk, J.M., Moy, A.P., Thorp, D.B., Noble, E.G., Taylor, A.W. and Cunningham, D.A. Determinants of oxygen uptake kinetics in older humans following single-limb endurance exercise training. Experimental Physiology 86.5, 659-665, 2001.
• Bell,C., Paterson,D.H., Kowalchuk, J.M., Padilla, J. and Cunnigham, D.A. A comparison of modelling techniques used to characterise oxygen uptake kinetics during the on-transient of exercise. Experimental Physiology 86.5,667-676, 2001.
• Monroe,M.B., Seals, D.R., Shapiro, L.F., Bell, C., Johnson, D.G. and Jones, P.P. Direct evidence for sympathetic support of resting metabolic rate in healthy adult humans. American Journal of Physiology: Endocrinology and Metabolism 280: E740-E744, 2001.
• Bell,C., Kowalchuk,J.M., Paterson, D.H., Scheuermann, B.W. and D.A. Cunningham. The effects of caffeine on the kinetics of O2 uptake, CO2 production and expired ventilation in humans during the on-transient of moderate and heavy intensity exercise. Experimental Physiology 84,761-774, 1999.
• Bell,C. , Paterson, D.H., Kowalchuk, J.M. and Cunningham, D.A. Oxygen uptake kinetics of older humans are slowed with age but are unaffected by hyperoxia. Experimental Physiology 84, 747-759, 1999.
• Bell,C., Paterson,D.H., Babcock, M.A. and D.A. Cunningham. Characteristics of the VO2 slow component during heavy exercise in subjects agedfrom 30 to 80 years. Advances in Experimental Medicine and Biology 450, 219-222, 1998.

Professional Presentations

• Sympatho-Adrenal Support of Energy Expenditure: Life after flux. Colorado Clinical Nutrition Research Unit, University of Colorado at Denver Health Sciences Center, April 2006.
• Autonomic Modulation of Energy Expenditure: Where Our Sympathies Lie. Department of Food Science and Human Nutrition, Colorado State University, February 2006.
• Autonomic Modulation of Energy Expenditure: Where Our Sympathies Lie. Biomedical Sciences Department, Colorado State University, October 2005.
• Sympathetic Nervous System Modulation of Energy Expenditure: Avoiding the Hazardous Waist. Conference on The Obesity Epidemic: Etiology, Prevention and Treatment, Colorado State University, April 2005.
• Sympathetic Nervous System Modulation of Energy Expenditure: Is Exercise a Beta Way to Offset Age-Associated Obesity? Faculty of Kinesiology, University of Calgary, Canada, March 2005.
• Sympathetic Modulation of Resting Metabolism In Older Humans. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, England, January 2004.
• SympatheticSupport of Metabolism: Is There No Beta Way To Offset Age-Associated Obesity? General Clinical Research Center Fall Scientific Symposium, University of Colorado, September 2003.
• Tonic Sympathetic Support of Resting Metabolism: Age, Sex, Flux and Rock n'Roll. Rocky Mountain Chapter of the American College of Sports Medicine, February 2003.
• Tonic Sympathetic Support of Resting Metabolism: Who Gives a Flux? Center for Human Nutrition Seminar Series, University of Colorado Health Sciences Center, April 2001.
• Control and Modeling of Oxygen Uptake Kinetics in Young and Older Adults: Gone With The Wind. Department of Kinesiology and Applied Physiology Colloquium Series, University of Colorado, October 1999.